18F-FDG Uptake Measurements in Malignant Solid Tumors on PET/CT and PET/MR

The Washington University

Status and phase: Completed; Phase 1

Conditions: Solid Tumor, Adult

Treatments: Device: Magnetic Resonance Imaging; Device: Computerized Tomography; Device: Positron Emission Tomography; Radiation: Fludeoxyglucose F 18

Study type: Interventional

Funder types: Other

Identifiers

NCT02717572

201508093

Details and patient eligibility

About

In the current study, the investigators plan to expand the knowledge of Positron Emission Tomography/Magnetic Resonance (PET/MR) reliability by assessing the repeatability of fludeoxyglucose (FDG) standardized uptake values (SUV) measurements, as well as apparent diffusion coefficients (ADC) measurements, in a broad population of patients with malignant solid tumors.

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with histologically confirmed malignant solid tumors (local or metastatic, newly diagnosed or recurrent disease).
• Patient must have at least one lesion measuring ≥ 2.0 cm.
• 18 years of age or older.
• Ability to provide informed consent.

Exclusion criteria

• Cancer therapy within 30 days of baseline imaging.
• Uncontrolled intercurrent illness including, but not limited to active infections.
• Patients with insulin-dependent diabetes.
• Patients with metal devices in the body including, but not limited to metallic joint prostheses, artificial heart valves, pacemakers, and cochlear implants.
• Patients who are pregnant or nursing.
• Inability to tolerate 60 minutes of PET imaging.
• Inability to comply with study procedures.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

FDG-PET/CT and FDG-PET/MR

Experimental group

Description:

* 10 mCI fludeoxyglucose IV bolus approximately 60 minutes before first PET/CT * Immediately following PET/CT scan, the participant will be moved to PET/MR scanner * The scans will take place at baseline and also one more time point between Day 1 and Day 7. There needs to be at least 24 hours between the baseline and repeat imaging

Treatment:

Radiation: Fludeoxyglucose F 18

Device: Positron Emission Tomography

Device: Computerized Tomography

Device: Magnetic Resonance Imaging