18F-FDOPA PET/CT Imaging in Patients Undergoing Metabolic Surgery

Korea University

Status

Unknown

Conditions

Obesity

Diabetes Mellitus, Type 2

PreDiabetes

Treatments

Procedure: Metabolic Surgery

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT03821961

STARDOM-PET

Details and patient eligibility

About

The aim of the study is to compare the endocrine function of pancreas between pre and post metabolic surgery in patients with type 2 diabetes or prediabetes. The study will examine the endocrine function of pancreas using 18F-FDOPA PET/CT imaging and various biochemical laboratory tests

Enrollment

30 estimated patients

Sex

All

Ages

19+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Type 2 diabetes or prediabetes
Body mass index >25.0 kg/m2
Written informed consent

Exclusion criteria

Diabetes induced by chronic pancreatitis or pancreas cancer
Chronic glucocorticoid usage
Significant coronary artery disease or cerebrovascular disease within the previous 3 months
Uncompensated congestive heart failure
Severe pulmonary disease defined as FEV1 < 50% of predicted value
End stage renal disease on dialysis
Acute infectious disease within the previous 3 months
Pulmonary thromboembolism or thrombophlebitis within the previous 3 months
History of cancer (except for basal cell skin cancer or cancer in situ)
Prior gastrointestinal surgery (except for appendectomy or hemorrhoidectomy)
Gastrointestinal disorders, malabsorptive disorders, or inflammatory bowel disease
History of chronic liver disease (except for NAFLD/NASH)
Psychiatric disorders including dementia, active psychosis, severe depression requiring > 2 medications, history of suicide attempts, alcohol or drug abuse within the previous 5 years