18F-MFBG Cardiac Imaging for Heart Failure Administration

S

Sichuan Provincial People's Hospital

Status

Invitation-only

Conditions

Rest Gated Myocardial Perfusion Imaging in Heart Failure

Treatments

Diagnostic Test: Standard medical care for heart failure

Study type

Observational

Funder types

Other

Identifiers

NCT06149195
CMFBG202311

Details and patient eligibility

About

The clinical feasibility of 18F-FMBG cardiac PET imaging will be observed in sympathetic nervous system activity in patients with heart failure, predicted cardiac events, guided ICD implantation, and evaluated therapy efficiency.

Full description

This is a prospective, single-center clinical study, using18F-meta-fluorobenzylguanidine (18F-MFBG) cardiac PET imaging to present the sympathetic nerve status in heart failure, including ICD implantation. Through follow-up, we analyze the correlation between the distribution of the tracer in the heart and the functions and progression of the patients, including the occurrence of ventricular arrhythmias and sudden cardiac death, And further investigate the guiding value of 18F-MFBG cardiac sympathetic nerve imaging in the screening of ICD implantation patients, including primary and secondary prevention, reducing the cost of ICD implantation and related complications. Furthermore, to evaluate the therapy efficacy for these patients with heart failure using 18F-MFBG cardiac imaging has been considered.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 1. Clinically confirmed patient with chronic heart failure, LVEF ≤ 40%, cardiac function NYHA 2-3 grade, survival period greater than 1 year, evaluated by the Heart Failure Center of Sichuan Provincial People's Hospital.
  • 2. Chronic heart failure patients were evaluated by the Cardiology Department of Sichuan Provincial People's Hospital 5-10 days before ICD implantation.
  • 3. All patients above have signed an informed consent form.

Exclusion criteria

  • 1. Heart failure, heart function NYHA levels ⅠOR Ⅳ.
  • 2. The patient has already implanted ICD or CRT.
  • 3. Heart transplant patients.
  • 4. Patients with malignant tumors.
  • 5. Heart valve disease.
  • 6. Myocardial infarction occurred within the past three months.
  • 7. The patient has contraindications for ICD implantation surgery.
  • 8. The patient does not cooperate or is unwilling to conduct the study.

Trial design

100 participants in 1 patient group

positive
Description:
positive imaging, referring to the tracer absented in the left myocardium whether diffuse or localized on 18F-FMBG cardiac imaging.
Treatment:
Diagnostic Test: Standard medical care for heart failure

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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