1L- vs. 4L-PEG for Bowel Preparation Among Inpatients.

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Completed

Conditions: Hospitalized Patients; Bowel Preparation; Colonoscopy

Treatments: Drug: 4L-PEG; Drug: 1L-PEG

Study type: Observational

Funder types: Other

Identifiers

NCT04310332

QIPS propensity score matching

Details and patient eligibility

About

Background and aims: Inpatients are at high risk for inadequate colon cleansing. Experts recommend 4L-polyethylene-glycol (PEG) solution because of its effectiveness and safety profile. A higher colon cleansing adequacy rate for a hyperosmolar 1L-PEG plus ascorbate prep has been recently reported in an observational study among more than 1,000 inpatients. Thus, the present study is aimed at determining whether 1L-PEG outperforms 4L-PEG among inpatients, through a propensity score-matching between the two groups in order to correct for confounders.

Enrollment: 1,004 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult inpatients scheduled for colonoscopy for any indication within the normal process of care.

Exclusion criteria

• patients who underwent emergency or elective therapeutic colonoscopies (e.g. polypectomy, endoscopic mucosal resection, endoscopic submucosal dissection)
• patients who underwent bowel preparation outside the hospital

Trial design

1,004 participants in 2 patient groups

1L-PEG

Description:

Hospitalized patients who are prescribed colonoscopy with 1L-polyethylene glycole (PEG) plus ascorbic acid as bowel preparation.

Treatment:

Drug: 1L-PEG

4L-PEG

Description:

Hospitalized patients who are prescribed colonoscopy with 4L-polyethylene glycole (PEG) as bowel preparation.

Treatment:

Drug: 4L-PEG