24 Hrs Histamine Profile in Healthy Persons and Patients With Food Intolerance

University of Erlangen-Nürnberg Medical School

Status: Completed

Conditions: IBS; Allergy

Treatments: Other: blood profile

Study type: Observational

Funder types: Other

Identifiers

NCT02293343

Histamine profile 1

Details and patient eligibility

About

Over 24 hrs serum and plasma samples were collected every 3 hrs. With this a day histamine profile was created. 15 healthy persons with 20 patients with a high level of IgE in serum and 20 patients with afflictions but no high IgE level were compared. Measurment of histamine in plasma, urine and stool were realized. In addition to that Diaminoxidase, TNF alpha and IgE Antibodies were measured.

Enrollment: 65 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects
• appropriate invalid persons

Exclusion criteria

• pregnant and weaning persons

Trial design

65 participants in 3 patient groups

control group

Description:

healthy subjects

Treatment:

Other: blood profile

IgE positive

Description:

patients with high IgE level in serum

Treatment:

Other: blood profile

IBS patients

Description:

patients with afflictions, but no high IgE level and suspicion on histamine intolerance

Treatment:

Other: blood profile