3 Ultrasound Guided Plane Blocks for Perioperative Analgesia in Patients Undergoing Radical Cystectomy

Nazmy Edward Seif

Status: Completed

Conditions: Block; Surgery; Analgesia; Cancer, Bladder; Anesthesia

Treatments: Procedure: Quadratus Lumborum Plane Block; Procedure: Thoracic Paravertebral Plane Block; Procedure: Erector Spinae Plane Block

Study type: Interventional

Funder types: Other

Identifiers

NCT05278598

3USGPBPORC

Details and patient eligibility

About

Radical cystectomy is the gold standard treatment for muscle invasive bladder cancer as well as some T1 and non-invasive disease. It is a major operation with significant perioperative morbidity and complications. Pain is one of the most important complications to be managed.

Regional blocks as a part of multi-modal analgesia are considered main strategies of Enhanced Recovery after Surgery (ERAS) decreasing post-operative complications including post-operative pain and post-operative hospital stay. They also have an upper hand over systemic intravenous opioids decreasing the risk for post-operative delirium specially in old age patients. Thoracic paravertebral plane block (TPVPB), intra muscular quadratus lumborum plane block (QLPB) and erector spinae plane block (ESPB) are among these regional anesthesia techniques for pain management.

Erector spinae plane block is an emerging block, with low risk and more feasibility, but efficacy hasn't been compared to quadratus lumborum and paravertebral plane blocks altogether in radical cystectomy surgeries.

All these blocks are effective in reducing postoperative pain and the need of analgesia in radical cystectomy surgery; this is a comparative study between the three blocks in this population.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) class II - III.
• Adult patients scheduled for radical cystectomy.

Exclusion criteria

• Patient refusal.
• Uncooperative patients.
• Patients with known allergies to local anesthetics.
• Bleeding disorders or coagulopathy.
• Anatomical abnormality or infection at injection site.
• Patients receiving opioids for chronic analgesic therapy.
• Spinal anesthesia or any other regional anesthesia.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups

ESPB group

Active Comparator group

Description:

Erector Spinae Plane Block

Treatment:

Procedure: Erector Spinae Plane Block

TPVPB group

Active Comparator group

Description:

Thoracic Paravertebral Plane Block

Treatment:

Procedure: Thoracic Paravertebral Plane Block

QLPB group

Active Comparator group

Description:

Quadratus Lumborum Plane Block

Treatment:

Procedure: Quadratus Lumborum Plane Block