3 Ultrasound Guided Plane Blocks for Perioperative Analgesia in Patients Undergoing Radical Cystectomy

N

Nazmy Edward Seif

Status

Completed

Conditions

Block
Surgery
Analgesia
Cancer, Bladder
Anesthesia

Treatments

Procedure: Quadratus Lumborum Plane Block
Procedure: Thoracic Paravertebral Plane Block
Procedure: Erector Spinae Plane Block

Study type

Interventional

Funder types

Other

Identifiers

NCT05278598
3USGPBPORC

Details and patient eligibility

About

Radical cystectomy is the gold standard treatment for muscle invasive bladder cancer as well as some T1 and non-invasive disease. It is a major operation with significant perioperative morbidity and complications. Pain is one of the most important complications to be managed. Regional blocks as a part of multi-modal analgesia are considered main strategies of Enhanced Recovery after Surgery (ERAS) decreasing post-operative complications including post-operative pain and post-operative hospital stay. They also have an upper hand over systemic intravenous opioids decreasing the risk for post-operative delirium specially in old age patients. Thoracic paravertebral plane block (TPVPB), intra muscular quadratus lumborum plane block (QLPB) and erector spinae plane block (ESPB) are among these regional anesthesia techniques for pain management. Erector spinae plane block is an emerging block, with low risk and more feasibility, but efficacy hasn't been compared to quadratus lumborum and paravertebral plane blocks altogether in radical cystectomy surgeries. All these blocks are effective in reducing postoperative pain and the need of analgesia in radical cystectomy surgery; this is a comparative study between the three blocks in this population.

Enrollment

120 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society of Anesthesiologists (ASA) class II - III.
  • Adult patients scheduled for radical cystectomy.

Exclusion criteria

  • Patient refusal.
  • Uncooperative patients.
  • Patients with known allergies to local anesthetics.
  • Bleeding disorders or coagulopathy.
  • Anatomical abnormality or infection at injection site.
  • Patients receiving opioids for chronic analgesic therapy.
  • Spinal anesthesia or any other regional anesthesia.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

120 participants in 3 patient groups

ESPB group
Active Comparator group
Description:
Erector Spinae Plane Block
Treatment:
Procedure: Erector Spinae Plane Block
TPVPB group
Active Comparator group
Description:
Thoracic Paravertebral Plane Block
Treatment:
Procedure: Thoracic Paravertebral Plane Block
QLPB group
Active Comparator group
Description:
Quadratus Lumborum Plane Block
Treatment:
Procedure: Quadratus Lumborum Plane Block

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems