31P Magnetic Resonance Spectroscopy Fructose Study (31PMRS_FRU)

Stephen Bawden

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Fructose

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02217605

A32006_FRU

Details and patient eligibility

About

The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.

Full description

This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels

Enrollment: 10 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Age 18 - 30
• BMI 20 - 27 kg/m^2
• Healthy

Exclusion criteria

• Smokers
• Liver disease or Metabolic Disorders
• Metal implants (not suitable for MRI)

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Fructose

Experimental group

Description:

Oral Fructose Challenge (75 g fructose in 500 ml water) followed by 75 minutes 31P MRS

Treatment:

Dietary Supplement: Fructose