31P-MRS and Huntington Disease (PRO-MH)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Huntington Disease

Treatments: Other: 31P-MR spectroscopy; Other: 31P-RMN spectroscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT01359774

2011-A00137-34 (Registry Identifier)

C10-56

Details and patient eligibility

About

The purpose of this study is to identify and quantify a brain energy deficit in Huntington patients, using 31P-RMN spectroscopy.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 5<UHDRS<50
• Age>18 years
• Ability to undergo MR scanning
• Covered by french social security

Exclusion criteria

• Evidence of psychiatric disorder
• Attendant neurological disorder
• Contraindications to MRI (claustrophobia, metallic or material implants)
• Severe head injury
• Unable to understand the protocol
• Pregnancy
• Failure to give informed consent
• Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)
• Unwillingness to be informed in case of abnormal MRI

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Healthy volunteers

Other group

Treatment:

Other: 31P-MR spectroscopy

Huntington patients

Other group

Treatment:

Other: 31P-RMN spectroscopy