3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Encephalopathy; Multiple Sclerosis; Optic Neuritis

Treatments: Diagnostic Test: Magnetic Resonance Imaging

Study type: Observational

Funder types: NETWORK

Identifiers

NCT04792866

CE_20200204_1_ALR

Details and patient eligibility

About

3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal suggestive of inflammation whereas brain examination is preferably performed using a 3D FLAIR sequence to highlight signs of spatial dissemination and lesions suggestive of multiple slerosis (MS).

Recently, a study based on a small number of patients showed the interest of 3D FLAIR in the detection of the hypersignal of the optic nerve.The objective of this retrospective study is to determine whether a single 3D FLAIR sequence allows simultaneous exploration of the optic nerve and the brain for the positive diagnosis of optic neuropathy and/or MS.

Enrollment: 1,200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Decrease in visual acuity explored in MRI between january 2018 and january 2020

Exclusion criteria

• Past history of episode of Optic neuritis