3D Imaging: Prognostic Role in Pulmonary Arterial Hypertension (HTP3S)

Centre Hospitalier Universitaire de Nice

Status: Unknown

Conditions: Pulmonary Arterial Hypertension

Treatments: Device: 3D right ventricular imaging echocardiographic

Study type: Observational

Funder types: Other

Identifiers

NCT02799979

14-AOI-08

Details and patient eligibility

About

Pulmonary hypertension is a rare and severe disease, affecting a young population. Survival is very poor and has been closely related to right ventricular dysfunction. Current prognostic equations rely mostly on right heart catheterization data. The identification of simple echocardiographic prognostic factor is urgently needed. It could help identifying with a non invasive method, high risk patients who could benefit from an intensive specific therapy. 3D right ventricular imaging is a new echocardiographic tool which provides RV volumic analysis, RV ejection fraction, overcoming the classical limits of 2D ultrasound.

The aim of this study is to validate a new software for 3D analysis of the right ventricle and assess its prognostic role in pulmonary hypertension.

To do so, the investigators will realize a prospective monocentric longitudinal cohort study, including 100 pulmonary hypertension patients. Echocardiographic data will be collected at baseline and after 6 months.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients > 18 years old
• Pulmonary hypertension diagnosed by right heart catheterization
• Informed consent obtained
• Affiliation to the French national health insurance

Exclusion criteria

• Associated significant left heart disease
• Sub-optimal acoustic windows
• Patient unable to attend follow-up visits

Trial design

150 participants in 2 patient groups

Case

Description:

Echocardiographic data : 3D right ventricular imaging on 100 pulmonary hypertension patients at Baseline and after six months

Treatment:

Device: 3D right ventricular imaging echocardiographic

Control

Description:

Echocardiographic data : 3D right ventricular Imaging on 50 patients without pulmonary hypertension only at baseline

Treatment:

Device: 3D right ventricular imaging echocardiographic