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3D Imaging: Prognostic Role in Pulmonary Arterial Hypertension (HTP3S)

C

Centre Hospitalier Universitaire de Nice

Status

Unknown

Conditions

Pulmonary Arterial Hypertension

Treatments

Device: 3D right ventricular imaging echocardiographic

Study type

Observational

Funder types

Other

Identifiers

NCT02799979
14-AOI-08

Details and patient eligibility

About

Pulmonary hypertension is a rare and severe disease, affecting a young population. Survival is very poor and has been closely related to right ventricular dysfunction. Current prognostic equations rely mostly on right heart catheterization data. The identification of simple echocardiographic prognostic factor is urgently needed. It could help identifying with a non invasive method, high risk patients who could benefit from an intensive specific therapy. 3D right ventricular imaging is a new echocardiographic tool which provides RV volumic analysis, RV ejection fraction, overcoming the classical limits of 2D ultrasound.

The aim of this study is to validate a new software for 3D analysis of the right ventricle and assess its prognostic role in pulmonary hypertension.

To do so, the investigators will realize a prospective monocentric longitudinal cohort study, including 100 pulmonary hypertension patients. Echocardiographic data will be collected at baseline and after 6 months.

Enrollment

150 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients > 18 years old
  • Pulmonary hypertension diagnosed by right heart catheterization
  • Informed consent obtained
  • Affiliation to the French national health insurance

Exclusion criteria

  • Associated significant left heart disease
  • Sub-optimal acoustic windows
  • Patient unable to attend follow-up visits

Trial design

150 participants in 2 patient groups

Case
Description:
Echocardiographic data : 3D right ventricular imaging on 100 pulmonary hypertension patients at Baseline and after six months
Treatment:
Device: 3D right ventricular imaging echocardiographic
Control
Description:
Echocardiographic data : 3D right ventricular Imaging on 50 patients without pulmonary hypertension only at baseline
Treatment:
Device: 3D right ventricular imaging echocardiographic

Trial contacts and locations

1

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Central trial contact

PAMELA MOCERI, MD

Data sourced from clinicaltrials.gov

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