3T MR Angiography of the Hepatic Vasculature

University of Colorado Denver (CU Denver)

Status: Terminated

Conditions: Liver Blood Supply

Treatments: Diagnostic Test: Compurtized Tomgraphy (CT); Diagnostic Test: Magnetic Resonance Imaging (MRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT02299934

14-1213

Details and patient eligibility

About

This study plans to learn more about the two Magnetic Resonance Angiography (MRA) techniques.

Full description

This study will use two Magnetic Resonance Angiography (MRA) techniques that will look at participants liver veins and arteries without giving a coloring matter (contrast) before taking the images. Investigators propose to evaluate the usefulness of these two new techniques, which do not involve exposing participants to radiation or contrast.

Enrollment: 13 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects that fulfill the criteria for living liver donation and are evaluated for the procedure with CT and MR.

Exclusion criteria

• Unable to give informed consent

• Unable to comply with breathing or other imaging related instructions resulting in inability to obtain diagnostic quality MRI studies

• Not suitable to undergo MRI with a gadolinium-based contrast agent because of:

  • Claustrophobia, unless patient agrees to sedation measures per institutional standard practice during MR imaging
  • Presence of metallic objects or implanted medical devices in body per institutional safety standards
  • Weight greater than that allowable by the MR table
  • Renal failure, as determined by estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 by the Modification of Diet in Renal Disease (MDRD) model based on a serum creatinine level obtained within 28 days prior to enrollment
  • Known allergy-like reaction to contrast media (gadolinium) or moderate or severe allergic reactions to one or more allergens as defined by the American College of Radiology (ACR), and unwillingness to undergo pre-treatment as defined by the institution's policy and/or ACR guidance
  • Pregnancy (if a female is of childbearing potential --defined as a premenopausal female capable of becoming pregnant --a pregnancy test should be done)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 1 patient group

Subjects who fulfill the criteria for living liver donation

Other group

Description:

Subjects who fulfill the criteria for living liver donation and are evaluated for the procedure with Computerized Tomography (CT) and Magnetic Resonance Imaging (MRI).

Treatment:

Diagnostic Test: Magnetic Resonance Imaging (MRI)

Diagnostic Test: Compurtized Tomgraphy (CT)