4beta-hydroxycholesterol in Cirrhosis

University of Oulu

Status: Suspended

Conditions: Cirrhosis, Liver

Treatments: Other: There is no intervention, only research blood samples are collected

Study type: Observational

Funder types: Other

Identifiers

NCT04199910

4bHC kirroosissa

Details and patient eligibility

About

The aim is to evaluate the levels of oxysterols and especially 4beta-hydroxycholesterol in patients with liver cirrhosis. Three cirrhosis cohorts are recruited: patients treated with spironolactone, patients treated with rifaximin, patients without spironolactone or rifaximin. Also three other control cohorts are recruited: patients with pneumonia, patients with Crohn's disease, patients with ulcerative colitis. The effect of the cirrhosis and its medications spironolactone and rifaximin are compared to control groups.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with cirrhosis, pneumonia, Crohn's disease or colitis ulcerosa
• Treated in the ward 42 of the Oulu University Hospital

Exclusion criteria

• None

Trial design

120 participants in 6 patient groups

Liver cirrhosis with spironolactone

Treatment:

Other: There is no intervention, only research blood samples are collected

Liver cirrhosis with rifaximin

Treatment:

Other: There is no intervention, only research blood samples are collected

Liver cirrhosis without spironolactone or rifaximin

Treatment:

Other: There is no intervention, only research blood samples are collected

Pneumonia

Treatment:

Other: There is no intervention, only research blood samples are collected

Crohn's disease

Treatment:

Other: There is no intervention, only research blood samples are collected

Ulcerative colitis

Treatment:

Other: There is no intervention, only research blood samples are collected