68Ga-Citrate PET of Healthy Volunteers (SITRAT)

Turku University Hospital (TYKS)

Status: Completed

Conditions: Healthy

Treatments: Other: Gallium-68 citrate

Study type: Interventional

Funder types: Other

Identifiers

NCT01951300

167/2013

Details and patient eligibility

About

This study investigates whole-body distribution kinetics of intravenously administered Gallium-69 (68Ga) citrate by positron emission tomography (PET)/computed tomography (CT). Thereafter, radiation dosimetry of 68Ga-citrate PET/CT will be determined.

Full description

Six healthy male volunteers are recruited in this study. Gallium-68 citrate radiopharmaceutical is intravenously injected as a bolus and whole-body distribution kinetics are studied by dynamic whole-body positron emission tomography/computed tomography. During imaging, serial venous blood samples are drawn, plasma is separated and radioactivity is measured by gamma counter. Immediately after imaging session, urine is voided and radioactivity is measured by gamma counting. As a final point, radiation dosimetry due to single Gallium-68 citrate injection is determined.

Enrollment: 6 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy 18-100 year-old men

Exclusion criteria

• ongoing infection/inflammation proven by blood or other tests

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

Gallium-68 citrate

Other group

Description:

Intravenous bolus injection of 200 MBq of Gallium-68 citrate

Treatment:

Other: Gallium-68 citrate