71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women (17b-ACO)

Federal University of Rio Grande do Sul

Status: Completed

Conditions: Polycystic Ovary Syndrome

Treatments: Drug: oral contraceptive pill

Study type: Interventional

Funder types: Other

Identifiers

NCT01372293

04-245

Details and patient eligibility

About

An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.

Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the investigators hypothesis is that women with PCOS and with the variant allele G have a poor response on hirsutism and on hormonal and metabolic variables after oral contraceptive pill (OCP) treatment for 6 months.

Enrollment: 49 patients

Sex: Female

Ages: 15 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hirsute women with polycystic ovary syndrome

Exclusion criteria

• Use of any drugs known to interfere with hormone levels for at least 3 months before the study
• Women with type 2 diabetes, homa index > 3.8, liver or renal disease or thyroid dysfunction
• Other hyperandrogenic disorders than PCOS

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)