99mTc-CNDG SPECT/CT in Brain Tumors

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Not yet enrolling

Conditions: Intracranial Tumor

Treatments: Diagnostic Test: 99mTc-CNDG SPECT/CT

Study type: Interventional

Funder types: Other

Identifiers

NCT06362304

2024-DG-01

Details and patient eligibility

About

The goal of this clinical trial is to evaluate the value of 99mTc-CNDG for diagnosis of brain tumors by comparing it with 18F-FDG-PET. The main questions it aims to answer are:

1. What is the diagnostic consistency between 99mTc-CNDG and 18F-FDG?
2. What is the correlation between the SUVmax value of 99mTc-CNDG and tumor type?

Participants will:

Receive18F-FDG-PET and 99mTc-CNDG examination within 2 weeks before surgery. Obtain pathological diagnosis by surgery or biopsy as the gold standard.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with clinical diagnosis of brain tumor;
• Be at least 18 years old;
• The final pathological results could be obtained by surgery or biopsy;
• Informed consent and the ability to be followed up;
• Those who did not meet the exclusion criteria.

Exclusion criteria

• Insulin-dependent diabetes mellitus or fasting blood glucose >7 mmol/L before 99mTc-CNDG injection;
• Severe liver or kidney disease (serum creatinine level >3.0mg/dL or any liver enzyme level ≥ 5 times the upper limit of normal);
• Severe hypersensitivity or hypersensitivity to radiocontrast agents;
• Claustrophobia (inability to undergo SPECT/CT or PET/CT scans);
• Patients receiving radiotherapy and chemotherapy;
• Being pregnant or breastfeeding.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

intracranial tumor

Experimental group

Treatment:

Diagnostic Test: 99mTc-CNDG SPECT/CT