99mTc-CNDG SPECT/CT in Brain Tumors

Chinese Academy of Medical Sciences & Peking Union Medical College logo

Chinese Academy of Medical Sciences & Peking Union Medical College

Status

Not yet enrolling

Conditions

Intracranial Tumor

Treatments

Diagnostic Test: 99mTc-CNDG SPECT/CT

Study type

Interventional

Funder types

Other

Identifiers

NCT06362304
2024-DG-01

Details and patient eligibility

About

The goal of this clinical trial is to evaluate the value of 99mTc-CNDG for diagnosis of brain tumors by comparing it with 18F-FDG-PET. The main questions it aims to answer are: What is the diagnostic consistency between 99mTc-CNDG and 18F-FDG? What is the correlation between the SUVmax value of 99mTc-CNDG and tumor type? Participants will: Receive18F-FDG-PET and 99mTc-CNDG examination within 2 weeks before surgery. Obtain pathological diagnosis by surgery or biopsy as the gold standard.

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with clinical diagnosis of brain tumor;
  • Be at least 18 years old;
  • The final pathological results could be obtained by surgery or biopsy;
  • Informed consent and the ability to be followed up;
  • Those who did not meet the exclusion criteria.

Exclusion criteria

  • Insulin-dependent diabetes mellitus or fasting blood glucose >7 mmol/L before 99mTc-CNDG injection;
  • Severe liver or kidney disease (serum creatinine level >3.0mg/dL or any liver enzyme level ≥ 5 times the upper limit of normal);
  • Severe hypersensitivity or hypersensitivity to radiocontrast agents;
  • Claustrophobia (inability to undergo SPECT/CT or PET/CT scans);
  • Patients receiving radiotherapy and chemotherapy;
  • Being pregnant or breastfeeding.

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

intracranial tumor
Experimental group
Treatment:
Diagnostic Test: 99mTc-CNDG SPECT/CT

Trial contacts and locations

0

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Central trial contact

Zhaohui Zhu

Data sourced from clinicaltrials.gov

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