a 3.0T Magnetic Resonance Imaging Study

Huazhong University of Science and Technology

Status: Unknown

Conditions: Primary Open Angle Glaucoma

Study type: Observational

Funder types: Other

Identifiers

NCT01346904

POAG3243

Details and patient eligibility

About

Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)
• matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )

Exclusion criteria

• optic neuropathy
• neurological disorder
• other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.