A Better Choice for Patients Undergoing Endovascular Coil Embolization

China Medical University, China

Status and phase: Completed; Phase 4

Conditions: Intracranial Aneurysms

Treatments: Drug: sevoflurane and 1 μg/kg dexmedetomidine; Drug: sevoflurane and 0.5 μg/kg dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01722409

20121009

Details and patient eligibility

About

The investigators designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine on the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.

Enrollment: 64 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:18-65 years old ASA I or ASA II patients undergoing ECE treatment for intracranial aneurysms were included.

Exclusion Criteria:Patients were excluded based on the following parameters: older than 65 yrs, a history of mental illness, recent use of sedatives or analgesics and with sensation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 3 patient groups

sevoflurane and saline infusion

No Intervention group

Description:

After induction of general anesthesia, Group S received a placebo infusion of normal saline.

sevoflurane and 0.5 μg/kg dexmedetomidine

Experimental group

Description:

After induction of general anesthesia, Group DEX1 received a single dexmedetomidine dose of 0.5 μg/kg over 10 minutes.

Treatment:

Drug: sevoflurane and 0.5 μg/kg dexmedetomidine

sevoflurane and 1 μg/kg dexmedetomidine

Experimental group

Description:

After induction of general anesthesia, Group DEX2 received a single dexmedetomidine dose of 1 μg/kg over 10 minutes.

Treatment:

Drug: sevoflurane and 1 μg/kg dexmedetomidine