A Case-control Study on the Clinical Characteristics of 28-day and 90-day Death From Severe Anthrax

Qin Ning

Status: Enrolling

Conditions: Anthrax

Study type: Observational

Funder types: Other

Identifiers

NCT06365073

TJIRB20231276

Details and patient eligibility

About

This study is a clinical, multi-center, retrospective, case-control study. Patients clinically diagnosed with severe anthrax who meet the inclusion and exclusion criteria will be included in this study for analysis. Respiratory, circulation, nerve and other vital signs of patients with severe anthrax during hospitalization were recorded, and clinical data such as blood routine, blood biochemistry, coagulation function, myocardial injury, therapeutic drug use, and survival time of patients were recorded, as well as the survival situation of patients 28 days and 90 days after discharge.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The typical bacilli with capsules were found in smear examination and culture of various secretions, excretions, blood and cerebrospinal fluid.
2. Multiple organ dysfunction (MODS) in brain, heart, liver, kidney, coagulation or more than one organ failure.

Exclusion criteria

There are other conditions that affect short-term survival.

Trial design

80 participants in 2 patient groups

survival group

Description:

Patients who survived in 28 days/90 days

death group

Description:

Patients who survived in 28 days/90 days