A Clinical Follow-up Study of Heart Failure Patients.

Fudan University

Status: Unknown

Conditions: Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT03797742

HF201801

Details and patient eligibility

About

Heart failure (HF), a current worldwide pandemic with an unacceptable high level of morbidity and mortality, brings an enormous medical and societal burden. Chronic HF is characterized by progressive alteration of cardiac structure and function. But the molecular mechanism of these alterations is still not well-established and needs to be discussed further. HF is a highly heterogeneous disease that can be caused by a multiple of diseases. Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are the main causes of this syndrome. Although HF is the common manifestation of DCM and ICM, the etiology and pathogenesis are different. Understanding the different pathophysiological mechanisms will contribute to the prevention and individualized therapy of heart failure. Therefore, this study aims to observation the different characteristics of the molecular biology and clinical courses in DCM and ICM patients.

Enrollment: 500 estimated patients

Sex: All

Ages: 15 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• LVEF≤ 55%
• enlarged left ventricular end-diastolic dimension
• ICM group: with history of MI or revascularization; ≥ 75% stenosis of LM or proximal LAD; ≥ 75% stenosis of two or more epicardial vessels.
• symptomatic heart failure

Exclusion criteria

• Known malignant tumour diseases
• Pregnancy or lactation period；
• Investigators think not suitable to participate in this trial.

Trial design

500 participants in 3 patient groups

NC

Description:

Patients without heart failure.

DCM

Description:

Dilated cardiomyopathy patients.

ICM

Description:

Ischemic cardiomyopathy patients.