A Clinical Study of BRCA and DNA Damage Repair Genes in Blood Samples of Chinese Pancreatic Cancer Patients

Shanghai Jiao Tong University

Status: Unknown

Conditions: Pancreatic Cancer

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT05138302

CPOG2021015

Details and patient eligibility

About

This study aims to know the status of BRCA and DDR genes in PDAC patients in China. Peripheral venous blood samples of the patients will be collected for next-generation sequencing of BRCA and DNA damage repair related genes. At the same time, it is necessary to record clinical information such as age, gender, tumor pathological type, tumor stage and grade, whether surgery is performed, the size of postoperative residual lesions, and treatment methods. Prognostic indicators include the association of factors such as PFS, ORR, and DCR are also recorded.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with pancreatic cancer
• PS score ≤ 2
• no severe heart, cerebrovascular disease, severe coagulation dysfunction or severe mental disorder

Exclusion criteria

• PS score > 2
• with severe heart, cerebrovascular disease, severe coagulation dysfunction or severe mental disorder