A Clinical Study of Subclinical Enthesitis and Synovitis in Patients With Vulgaris Psoriasis

The 306 Hospital of People's Liberation Army

Status: Unknown

Conditions: Vulgaris Psoriasis

Treatments: Other: PDUS examination

Study type: Observational

Funder types: Other

Identifiers

NCT02339636

306PLA-002

Details and patient eligibility

About

A clinical study of subclinical enthesitis and synovitis in patients with vulgaris psoriasis

Full description

A total of 100 patients with vulgaris psoriasis and 100 age-matched controls with other skin diseases, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded PDUS evaluation. Clinical assessment included demographics, severity of psoriasis, musculoskeletal clinical examination and sport activities. PDUS evaluation consisted of the detection of grey scale (GS) synovitis and synovial PD signal in joints of extremities, GS enthesopathy and entheseal PD signal in entheses of lower limbs.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age≥18years
• patients with vulgaris psoriasis(dur
• patients with other skin diseases without musculoskeletal disorders
• no joint involvement and no clinical symptoms and signs of enthesitis and synovitis

Exclusion criteria

• BMI≥24
• have history of gout or arthritis or peripheral neurological disease of lower extremity or trauma
• have received any systemic therapy(i.e.NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months
• pregnant or breast-feeding

Trial design

200 participants in 2 patient groups

case group

Description:

100 patients with vulgaris psoriasi without arthritis

Treatment:

Other: PDUS examination

control group

Description:

100 age-matched patients with other skin diseases without arthritis

Treatment:

Other: PDUS examination