A Clinical Trial to Explore the Safety and Efficacy of Three Different Doses of Pegaptanib Sodium in Patients With Wet Age-Related Macular Degeneration (AMD)

Eyetech Pharmaceuticals

Status and phase: Terminated; Phase 4

Conditions: Macular Degeneration

Treatments: Drug: Pegaptanib sodium

Study type: Interventional

Funder types: Industry

Identifiers

NCT00312351

EOP1014

Details and patient eligibility

About

The purpose of this trial is to compare the ability of three different doses of pegaptanib sodium to safely and effectively minimize fluid leakage within the eye, thereby stabilizing or improving vision in patients with wet AMD. The study will also examine the effects of pegaptanib sodium on the cornea and sensory retina of patients with wet AMD.

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects of either gender, aged 50 years or greater.
• Subfoveal choroidal neovascularization (CNV) due to AMD.
• Best corrected visual acuity in the study eye between 20/40 and 20/320.
• Normal electroretinogram, and corneal endothelial cell density of 1500 cells/mm2 or more.

Exclusion criteria

• Any prior photodynamic therapy (PDT) with Visudyne or thermal laser to the study eye.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind