A Closer Look at the Effect of Dextrose on Postoperative Nausea and Vomiting

Loma Linda University (LLU)

Status: Completed

Conditions: Postoperative Nausea and Vomiting

Treatments: Other: Intravenous fluid; Other: D5LR or lactated ringers

Study type: Interventional

Funder types: Other

Identifiers

NCT01123837

5100086

Details and patient eligibility

About

"The purpose of this investigator-initiated study is to see if giving dextrose fluid in the veins (IV) decreases the risk of postoperative nausea and vomiting (PONV) in female urologic, gynecologic and breast outpatient surgery patients and at what blood surgery level. The reason for this study is that IV dextrose has been shown to decrease the incidence of PONV and the use of medications to treat PONV, while leading to sooner discharge after surgery. This can decrease overall healthcare cost and improving patient satisfaction."

Enrollment: 202 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. ASA I or II
2. female urologic, gynecologic and breast surgery patients undergoing scheduled same day procedures at LLUMC Heart and Surgical Hospital

Exclusion criteria

1. age <18 or >65;
2. severe hypertension,diabetes mellitus, significant hepatic or renal disease
3. excessive blood loss
4. sustained (>10 min)>20% from baseline drop in BP after treatment
5. inability to follow protocol
6. refusal to sign consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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202 participants in 2 patient groups

D5LR

Active Comparator group

Description:

In the treatment group, a 250cc bolus over 2 hrs of D5LR will be initiated prior to the end of surgery and continued in PACU.Blood glucose will be measured at 3 different timepoints using a point of care testing device (Accu-Chek). We will be measuring changes in blood glucose levels associated with PONV and the type and number of rescue medicines given at 30, 60, and 120 minutes after anesthesia and the first postoperative morning

Treatment:

Other: Intravenous fluid

Other: D5LR or lactated ringers

lactated ringers

Active Comparator group

Description:

In the control group, a 250cc bolus over 2 hrs of LR will be initiated prior to the end of surgery and continued in PACU. Blood glucose will be measured at 3 different timepoints using a point of care testing device (Accu-Chek). We will be measuring changes in blood glucose levels associated with PONV and the type and number of rescue medicines given at 30, 60, and 120 minutes after anesthesia and the first postoperative morning.

Treatment:

Other: Intravenous fluid

Other: D5LR or lactated ringers