A Cold Physical Treatment to Manage Insulin Resistance (CTPMIR)

Xi'an Jiaotong University

Status: Completed

Conditions: Diabetes; Hyperinsulinemia; Hyperglycemia; Insulin Resistance; Obesity

Treatments: Device: Electroacupuncture; Procedure: Selective Cold

Study type: Interventional

Funder types: Other

Identifiers

NCT02852759

XJTU1AF-CRS-2016-018

Details and patient eligibility

About

Insulin resistant volunteers will choose to undergo an 8-week cold treatment, 2 hours per day, to selective regions of the body enriched with brown fat including neck, supraclavicular and interscapular regions) in combination with electroacupuncture (EA). Their insulin sensitivity and glucose and lipid homeostasis will be measured. The brown fat activation will be assessed by positron emission tomography and computed tomography (PET/CT)-scans and/or serum marker measurements.

Enrollment: 33 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI: 20-30
• Insulin resistant

Exclusion criteria

• uncontrolled hypertension
• insulin dependent diabetics
• heart diseases
• hyperthyroidism
• secondary obesity
• surgical operation within treatment or planned in two months
• pregnancy
• anemia
• liver or kidney failure
• cancer

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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33 participants in 2 patient groups

intervention group

Experimental group

Description:

Add Selective Cold and Electroacupuncture treatment to the existing treatment for patients with insulin resistance.

Treatment:

Device: Electroacupuncture

Procedure: Selective Cold

Intensive Care group

No Intervention group

Description:

continue the existing management of insulin resistance in these patients. They will receive the same follow up, examinations etc as intervention group.