A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults (ICLID)

S.LAB (SOLOWAYS)

Status: Not yet enrolling

Conditions: Dental Pain

Treatments: Dietary Supplement: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg; Dietary Supplement: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg; Other: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT06269406

SW008

Details and patient eligibility

About

Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.

Enrollment: 264 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Removal of 2 to 4 impacted third molars

Exclusion criteria

• Pregnancy or breastfeeding
• Ibuprofen contraindications.
• Allergy to any of the intervention components.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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264 participants in 3 patient groups, including a placebo group

Intervention Group ibuprofen 400 and Curcumin

Experimental group

Treatment:

Dietary Supplement: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg

Intervention Group ibuprofen 200 and Curcumin

Experimental group

Treatment:

Dietary Supplement: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg

Intervention Group ibuprofen 400 and placebo

Placebo Comparator group

Treatment:

Other: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure