A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment

Palo Alto Veterans Institute for Research

Status: Completed

Conditions: Amnestic Mild Cognitive Impairment

Treatments: Behavioral: Stretching Exercises; Behavioral: Cognitive Training; Behavioral: Combined Aerobic and Resistance Exercise

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT01962038

FAI0002AGG

Details and patient eligibility

About

The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.

Enrollment: 72 patients

Sex: All

Ages: 50 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of amnestic Mild Cognitive Impairment
• available informant
• visual and auditory acuity to allow neuropsychological testing
• willingness to participate in exercise training + cognitive training for 8 months
• approval of primary provider to participate in exercise trial

Exclusion criteria

• current severe psychiatric disorder
• diagnosis of dementia
• history of neurological or system illness affecting CNS function
• acute illness or unstable chronic illness
• current severe cardiac disease
• inability to exercise consistently because of orthopedic or musculoskeletal problems
• morbid obesity
• inability to read, verbalize understanding and voluntarily sign the informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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72 participants in 2 patient groups

Combined Aerobic and Resistance Exercise/Cognitive Training

Active Comparator group

Treatment:

Behavioral: Combined Aerobic and Resistance Exercise

Behavioral: Cognitive Training

Stretching Exercises/Cognitive Training

Active Comparator group

Treatment:

Behavioral: Cognitive Training

Behavioral: Stretching Exercises