A Community-based Prospective Cohort Study on Metabolic Dysfunction-Associated Fatty Liver Disease in Older Adults: From Metabolic Trajectories to Extrahepatic Outcomes (MAPS Cohort)

The Affiliated Hospital of Hangzhou Normal University

Status: Begins enrollment in 1 month

Conditions: NAFLD Cirrhosis; NAFLD( Non-alcoholic Fatty Liver Disease ); NAFLD and NASH

Study type: Observational

Funder types: Other

Identifiers

NCT07241195

SJP20250401

Details and patient eligibility

About

To establish a cohort of elderly fatty liver disease based on the community medical examination population. Through the large-scale cohort study, the risk factors affecting fatty liver in the elderly will be explored in depth from the aspects of lifestyle, environment and genetics, the development pattern and mechanism of fatty liver in the elderly will be analysed, and the health risk assessment system and Chinese standard for fatty liver in the elderly covering cardiovascular risk, risk of hepatic fibrosis and risk of sarcopenia will be established, so as to provide the scientific basis for the precise intervention of fatty liver in the elderly in China.

Enrollment: 20,000 estimated patients

Sex: All

Ages: 65 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ① Elderly people aged ≥65 years among permanent residents (living for more than 5 years) in the survey area;

  • Imaging diagnosis (ultrasound or FibroScan/FibroTouch) of fatty liver; -③ Voluntary participation in this study and signing an informed consent form.

Exclusion criteria

• ①Major disability, mental illness, major wasting disease, severe cardiac, pulmonary and renal insufficiency;

  • Patients with combined primary liver cancer or other types of cancer; -③Patients who have received liver transplant or other organ transplants.

Trial design

20,000 participants in 2 patient groups

control group

Observation Group

Description:

Lifestyle interventions