A Comparative Study Between Intrathecal Dexmedetomidine VS Ketamine With Intrathecal Bupivacaine in Orthopedic Lower Limb Surgeries.

Sohag University

Status: Not yet enrolling

Conditions: Bone Fracture

Treatments: Drug: Dexmedetomidine; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT05751304

Soh-Med-23-02-09

Details and patient eligibility

About

Orthopedic anaesthesia and acute postoperative pain management, two anesthesiology subspecialties,are getting more credit for reducing hospital stays, promoting functional recovery and improving patient satisfaction.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

-The study will include 100 adult patients (18 to 50 years old) with ASA physical status class I and class II undergoing orthopedic lower limb surgeries under itrathecal anathesia .

Exclusion criteria

• Patient refusal.
• Drug abuse.
• Patient with neurological, psychiatric or neuromuscular disease.
• Chronic pain on medicine.
• Known allergy to the study medications.
• Patients e contraindications to intrathecal anesthesia .

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Group D

Active Comparator group

Description:

(50 patients) will receive calculated dose of intrathecal hyperbaric bupivacaine 0.5 % according to body weight and 5μg dexametomidine.

Treatment:

Drug: Dexmedetomidine

Group K

Active Comparator group

Description:

(50 patients) will receive calculated dose of intrathecal hyperbaric bupivacaine 0.5 % according to body weight and 0.1 mg/kg ketamine.

Treatment:

Drug: Ketamine