A Comparative Study of GPI's DBS and Pallidotomy in the Treatment of Meige Syndrome

Peking University

Status: Unknown

Conditions: Blepharospasm Oromandibular Dystonia; Meige Disease; Blepharospasm; Blepharospasm of Left Eyelid; Meige Syndrome; Meig Syndrome; Blepharospasm of Both Eyelids; Meigs Syndrome; Blepharospasm of Right Eyelid

Treatments: Procedure: pallidotomy; Procedure: deep brain stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT04618887

MeigeSyndrome

Details and patient eligibility

About

In this study, we will compare the degree of postoperative symptom improvement, postoperative complication rate, postoperative quality of life improvement degree of patients with Meige syndrome undergoing pallidotomy (unilateral globus palliotomy) and deep brain stimulation (unilateral globus pallidus) ,in order to get the conclusion of the comparison of the clinical efficacy of the two surgical plans. In addition, possible predictive factors such as age, gender, age of onset, length of disease course, scale baseline score, preoperative brain PET-CT function analysis and other possible predictive factors are added for analysis, in order to find predictive factors that can guide the choice of surgical options.

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients confirmed Meige sydrome

Exclusion criteria

• Patients who cannot finish the neurosurgery or the postoperative evaluation

Trial design

100 participants in 1 patient group

Meige sydrome patients

Treatment:

Procedure: pallidotomy

Procedure: deep brain stimulation