A Comparative Study of ID Fellow-based VS. Pharmacist-based Antibiotic Pre-authorization (DUE)

Siriraj Hospital

Status: Completed

Conditions: No Specific Conditions Requires; All Hospitalzied Patients

Treatments: Procedure: ID fellow-based antibiotic pre-authorization; Procedure: Pharmacist-based antibiotic pre-authorization

Study type: Interventional

Funder types: Other

Identifiers

NCT01797133

647/2555(EC1)

Details and patient eligibility

About

We will conduct a cluster randomized controlled trial to compare two antibiotic pre-authorization strategies (Fellow-based vs. Pharmacist-based). We believe that amount and duration of antibiotic consumption would be lower in the pharmacist group while the clinical outcome would be equivalent between two groups.

Full description

Study design: A cluster randomized controlled trial Settings: 6 general medical wards at Siriraj Hospital, Bangkok, Thailand

Enrollment: 984 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized patients
• Received at least one dose of controlled antibiotics (Piperacillin/Tazobactam, Imipenem/Cilastatin, Meropenem or Doripenem)
• Each patient may be enrolled more than once, if he/she receives the controlled antibiotic for a new episode of infection (at least 48 hour apart)

Exclusion criteria

• Died prior to receive the controlled antibiotic

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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984 participants in 2 patient groups

Fellow arm

Active Comparator group

Description:

Patients in this arm will receive the ID fellow-based antibiotic pre-authorization intervention.

Treatment:

Procedure: ID fellow-based antibiotic pre-authorization

Pharmacist arm

Active Comparator group

Description:

Patients in this arm will receive the pharmacist-based antibiotic pre-authorization intervention.

Treatment:

Procedure: Pharmacist-based antibiotic pre-authorization