A Comparative Study of Platelet-Rich Plasma and Normal Saline Dressings in the Treatment of Chronic Wounds (PRP-NS Wound T)

Quaid-e-Azam Medical College

Status: Completed

Conditions: Wound Healing

Treatments: Procedure: Platelet-Rich Plasma (PRP) Injections

Study type: Interventional

Funder types: Other

Identifiers

NCT06849232

2381/DME/QAMC (Other Identifier)

2381/DME/QAMC Bahawalpur

Details and patient eligibility

About

This study aims to compare the effectiveness of Platelet-Rich Plasma (PRP) dressings versus Normal Saline dressings in the treatment of chronic wounds. Chronic wounds are slow-healing wounds that can cause significant discomfort, increase the risk of infections, and impact a patient's quality of life.

Platelet-Rich Plasma (PRP) is derived from the patient's own blood and contains growth factors that may help promote faster wound healing. On the other hand, Normal Saline dressings are commonly used as a standard wound care approach.

Participants in this study will be randomly assigned to receive either PRP dressings or normal saline dressings. The healing progress of their wounds will be monitored over a specified period to determine which treatment leads to better and faster healing.

The findings from this study may help improve wound care management and provide evidence for using PRP as an effective treatment for chronic wounds.

Enrollment: 156 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18-60 years of either gender were included if they had a chronic wound persisting for at least six weeks and with a size of at least 2 × 2 cm.

Exclusion criteria

• Patients were excluded if their wounds had existed for less than six weeks, if they had a previous history of PRP dressing use, or if they had documented hypersensitivity to PRP.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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156 participants in 2 patient groups

PRP Dressing Group

Experimental group

Description:

wounds were first cleaned with normal saline, followed by the injection of PRP, prepared from the patient's own blood by the hematology department, into the surrounding wound area twice weekly

Treatment:

Procedure: Platelet-Rich Plasma (PRP) Injections

Normal Saline Dressing Group

Active Comparator group

Treatment:

Procedure: Platelet-Rich Plasma (PRP) Injections