ClinicalTrials.Veeva

Menu

A Comparative Study of Prophylactic Anticoagulation in Meningioma Surgery

S

St. Olavs Hospital

Status

Completed

Conditions

Meningioma

Treatments

Drug: prophylactic enoxaparin
Procedure: non-prophylactic

Study type

Observational

Funder types

Other

Identifiers

NCT01941602
2013/884

Details and patient eligibility

About

The aim of the study is to compare different strategies for prevention of venous thromboembolism related to intracranial meningioma surgery. The investigators identified three hospitals where two have a very restrictive approach with respect to anticoagulant therapy while at the third hospital the use of anticoagulation the day before surgery was initiated as routine prophylaxis.

Based on this "natural experiment" it will be explored whether the use of anticoagulant prophylaxis is associated with reduced risk of venous thromboembolism and/or associated with increased risk of postoperative hemorrhage as compared to the 2 cohorts where this intervention were absent.

Enrollment

979 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • First included patient 1.january 2007 and latest included patient 1.july 2013 (allows for 30 day follow up with respect to morbidity)
  • Histological verification of a meningioma (of any grade) from the current surgery

Exclusion criteria

  • Intracranial surgery or venous thromboembolism the last 3 months

Trial design

979 participants in 2 patient groups

prophylactic
Description:
Prophylactic treatment with drugs to prevent venous thromboembolism in patients operated with open surgery for intracranial meningioma at the Department of neurosurgery at Karolinska Hospital, Stockholm, Sweden
Treatment:
Drug: prophylactic enoxaparin
non-prophylactic
Description:
No use of prophylactic treatment with drugs to prevent venous thromboembolism in patients operated with open surgery for intracranial meningioma at the Departments of neurosurgery at University Hospital North Norway (UNN) and St.Olavs University Hospital (Tromsø and Trondheim respectively, both Norway)
Treatment:
Procedure: non-prophylactic

Trial contacts and locations

3

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems