A Comparison Between Conventional Surgery and Piezosurgery

Damascus University

Status: Completed

Conditions: Third Molars Extraction

Treatments: Device: Piezosurgery

Study type: Interventional

Funder types: Other

Identifiers

NCT02495207

UDDS-OMFS-03-2015

Details and patient eligibility

About

Evaluation of the effect of conventional and piezo-surgery on the secretion of Heat Shock Protein (HSP70) and on the vial bone cells at the peripheral bone cut sides after the removal of impacted mandibular third molars on both sides of the jaw.

Full description

The study is about measuring the amount of HSP70 using Elisa kit for detecting HSP70 and mason trichrome for histological findings in which the study samples are patients who have bilateral impacted mandibular third molar to be extracted with bone removal. First we collect bone sample for mason trichrome with either method then we collect the second samples after removing most of the bones cover the impacted third molar for checking HSP70 levels. Then the bone samples are treated using a special protocol to eliminate the protein from bone samples for the Elisa analysis. The other bone samples are going to be studied under the microscope.

Enrollment: 15 patients

Sex: All

Ages: 16 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• bilateral identical impacted third molar that need at least 3 mm of bone removal

Exclusion criteria

• Pregnancy
• Smokers
• Infectious diseases
• Infections around third molars (i.e. pericoronitis).
• Alcoholic patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Conventional Surgery

No Intervention group

Description:

No intervention in this arm. The patients are going to undergo normal surgical intervention. Conventional surgery will be performed to extract the impacted third molars.

Piezosurgery

Experimental group

Description:

Patients here will undergo a piezosurgery to extract their third molars on both sides.

Treatment:

Device: Piezosurgery