A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

Baskent University

Status and phase: Unknown; Phase 4

Conditions: Coronary Artery Bypass Surgery

Treatments: Drug: Etomidate; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT01386229

KA-10-114

Details and patient eligibility

About

The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.

Enrollment: 40 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
• Patient's written informed consent for study participation
• Ejection fraction ≥ 35%

Exclusion criteria

• Allergy to study drugs
• Redo surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups

Ketamine

Active Comparator group

Treatment:

Drug: Ketamine

Etomidate

Active Comparator group

Treatment:

Drug: Etomidate