A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill

Barts & The London NHS Trust

Status: Completed

Conditions: Keratitis

Treatments: Other: Lacrilube ointment; Other: Hydrogel dressing

Study type: Interventional

Funder types: Other

Identifiers

NCT00513734

003171

Details and patient eligibility

About

Corneal damage in critically ill patients is common. There are currently two popular methods of treatment in the UK; hydrogel dressings and lubricating ointment. We propose to randomise patients to have a different treatment for each eye and see which one is more effective.

Full description

Microbial keratitis, particularly pseudomonas-related, has been widely reported amongst Intensive therapy unit (ITU) patients and the need for effective eye care in ITU has been recognised for some time. We compare two popular methods of eye care; a hydrogel dressing and lacrilube ointment. Each recruited patient had each eye randomised to different treatments. Daily ophthalmology ward rounds were undertaken to identify any corneal exposure keratopathy. Patients were removed from the trial if one eye developed significant exposure needing treatment.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients admitted to Intensive care and expected to stay for more than 2 days

Exclusion criteria

• Primary orbital injury

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

1

Active Comparator group

Description:

Geliperm Hydrogel Dressing

Treatment:

Other: Hydrogel dressing

2

Active Comparator group

Description:

Lacrilube ointment

Treatment:

Other: Lacrilube ointment