A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial

Yonsei University

Status and phase

Completed

Phase 4

Conditions

End Stage Renal Disease

Treatments

Drug: Propofol total intravenous anesthesia

Drug: Desflurane balanced anesthesia

Study type

Interventional

Funder types

Other

Identifiers

NCT01870011

4-2013-0208

Details and patient eligibility

About

Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term kidney dysfunction after renal transplantation. Protecting the kidney against I/R injury and maintaining renal function during renal transplant surgery is therefore very important in order to improve post-operative outcome. This purpose of this study is to investigate whether propofol anesthesia done in both kidney donors and recipients during deceased brain dead donor kidney transplantation is effective in reducing renal I/R injury via its antioxidant and antiinflammatory properties and improve post-transplant outcome compared to desflurane anesthesia.

Enrollment

6 patients

Sex

All

Ages

20 to 69 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult deceased brain dead kidney donors and recipients scheduled for renal transplantation

Exclusion criteria

Donor exclusion criteria:

(1) Refusal of legal guardian

Recipient exclusion criteria:
Patient refusal
Hypersensitivity to propofol, soybeans or peanuts
History of vitamin C or E intake within 5 days before surgery
History of acute myocardial infarct within 6 months before surgery
Congestive heart failure (NYHA III-IV)
Autoimmune disease patients
BMI over 30 kg/m2
Left ventricular ejection fraction less than 35% upon preoperative echocardiography