A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation

Yonsei University

Status and phase

Completed

Phase 4

Conditions

End Stage Liver Disease

Treatments

Drug: Desflurane balanced anesthesia

Drug: Propofol total intravenous anesthesia

Study type

Interventional

Funder types

Other

Identifiers

NCT02504138

4-2013-0454

Details and patient eligibility

About

Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term hepatic dysfunction after liver transplantation. Protecting the liver against I/R injury and maintaining hepatic function during transplant surgery is therefore very important in order to improve post-operative outcome. This purpose of this study is to investigate whether propofol anesthesia done in both liver donors and recipients during living-donor liver transplantation is effective in reducing liver I/R injury via its antioxidant and antiinflammatory properties and improve post-transplant outcome compared to desflurane anesthesia.

Enrollment

136 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

(1) Adult liver donors and recipients scheduled for liver transplantation

Exclusion criteria

Patient refusal
Hypersensitivity to propofol, soybeans or peanuts
History of vitamin C or E intake within 5 days before surgery
History of acute myocardial infarct within 6 months before surgery
Congestive heart failure (NYHA III-IV)
Autoimmune disease patients
BMI over 30 kg/m2
Left ventricular ejection fraction less than 35% upon preoperative echocardiography