Effects of Sodium Intake on Arterial Stiffness in Black Men and Women

Texas State University

Status: Completed

Conditions: Sodium Intake; Arterial Stiffness

Treatments: Dietary Supplement: High-sodium intake; Behavioral: Low-sodium intake

Study type: Interventional

Funder types: Other

Identifiers

NCT05815043

8663

Details and patient eligibility

About

The purpose of this study is to explore the influence of sodium intake on arterial stiffness in African American/Black adults.

Enrollment: 34 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• African American or Black
• Male or Female

Exclusion criteria

• pregnancy or within 60 days postpartum
• having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months
• infection (viral or other) within the past 4 weeks
• having adrenal or endocrine tumors (these could impact BP)
• renal disease defined as a glomerular filtration rate (GFR) of less than 60
• prior myocardial infarction
• known coronary heart disease
• personal history of stroke
• heart failure
• cardiac arrhythmias
• recent chest pain or dyspnea
• current insulin dependence
• currently undergoing chemotherapy or radiation
• identifying as transgender (the focus of this trial is biological sex)
• seated systolic or diastolic blood pressure of more than 149 mm Hg or 99 mm Hg, respectively

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Sequential Assignment

Masking: None (Open label)

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34 participants in 1 patient group

Low- and high-sodium intake

Experimental group

Description:

Participants will consume two different quantities of sodium per day for 3 days each.

Treatment:

Behavioral: Low-sodium intake

Dietary Supplement: High-sodium intake