A Comparison of the Perception of a Needle Injection Pain Between Cancer Patients Receiving Opioid Therapy Versus Opioid-naive Patients

Yonsei University

Status

Completed

Conditions

Cancer Patients

Treatments

Procedure: The local anesthetic injection

Study type

Interventional

Funder types

Other

Identifiers

NCT01704469

4-2012-0066

Details and patient eligibility

About

Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids. In humans, the evidence of OIH is strong but conflicting. Previous clinical studies mostly used experimental or non-standardized surgical stimuli to assess OIH. We therefore sought to certify a presence of OIH using a standardized, clinical pain stimuli in cancer patients receiving opioid therapy and opioid-naive patients.

Enrollment

80 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age 20-80
cancer patient
patient whom receiving opioid treatment, any acute or chronic pain condition amenable to a diagnostic/therapeutic nerve block or neuromodulation,and a regular analgesic regimen.

Exclusion criteria

patient who has any change in opioid or other analgesic medications less than 14 days prior to the scheduled procedure
an inability to understand English or adequately respond to the relevant questions