A Comprehensive Study to Isolate Tumor-initiating Cells From Human Epithelial Malignancies

Stanford University

Status: Withdrawn

Conditions: Bladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy); Bladder Cancer; Skin Cancers; Bladder (Urothelial, Transitional Cell) Cancer

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01060319

SU-11062009-4360 (Other Identifier)

BLDR0011

Details and patient eligibility

About

We hypothesize that all human malignancies harbour a subpopulation of tumor initiating cells/cancer stem cells (CSCs) that drives tumor development and potentially recurrence or metastasis of the disease. The primary aim of this study is to develop strategies for prospective isolation/enrichment of CSCs from human tumors of different tissue origins. In addition, we will characterize the signaling pathways and/or tumor specific antigens that are specific for CSCs, in order to specifically target these CSCs as the endpoint of this study.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:N/A. We will recruit all non-melanoma skin and bladder cancer patients that are recommended for surgical removal of tumor tissues. This includes patients from all ages, gender and ethnicity background. Our sample collection criteria based on the tumor size of individual (e.g. tumor samples will only be collected if it will not affect the pathological diagnosis or treatment procedures of patients). Exclusion Criteria:N/A