A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities

Leila DJABELKHIR

Status: Unknown

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Computerized Cognitive training

Study type: Interventional

Funder types: Other

Identifiers

NCT03195816

LUS3WMH

Details and patient eligibility

About

This is a non-pharmacological study evaluating the impact of a computerized cognitive stimulation program on verbal learning and on the progression white matter hyperintensities in elderly with mild cognitive impairment.

Full description

White matter hyperintensities (WMH) can appear in Mild Cognitive Impairment (MCI) and have been associated to executive, attention and processing speed deficits. Some findings indicate that the presence of WMH may contribute to Alzheimer's disease (AD) in addition to ß-amyloid, suggesting a greater vulnerability of MCI. One important challenge is to prevent or slowing down the progression of WMH. Few studies investigated the effects of computerized cognitive interventions in MCI with WMH, which deserve special attention. This study aim to investigate the effects of an intensive computer-based cognitive stimulation (CCS) program on the verbal learning in episodic memory in MCI with WMH and to explore the effects on the progression of WMH at 1-year interval.

Enrollment: 90 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Mild Cognitive Impairment
• With and without with matter hyperintensities
• MRI data available or accept to perform one
• No engagement in other cognitive intervention program

Exclusion criteria

• Psychiatric and neurological disorders
• History of alcohol or other substance consumption
• Sensory and or motor deficit that could interfere with the use of computer tool
• Refusal MRI.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups

computerized Cognitive training

Experimental group

Description:

Experimental group will receive 1 year of a computer-based cognitive stimulation program.

Treatment:

Behavioral: Computerized Cognitive training

MCI control group

No Intervention group

Description:

The control group will receive a usual standard care without engagement in intervention