A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study (CRACK-ANT)

University Hospital Center of Martinique

Status: Unknown

Conditions: Dependence, Cocaine

Treatments: Genetic: Collect 10 ml of Saliva for DNA extraction

Study type: Interventional

Funder types: Other

Identifiers

NCT01025219

09/B/01

Details and patient eligibility

About

The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be associated with genetic and genotypic characterisations, notably on the polymorphisms of the genes coding or regulating dopaminergic, norepinephrine and serotoninergic systems.

Full description

Genetic studies show an association between drug addiction and the dopaminergic system and its modulators. Nonetheless, results are contradictory, partially due to the heterogeneity of the phenotype addiction. Placed on the trafficking route of cocaine, and homogeneously populated, Martinique is of particular interest for the study of the vulnerability of the crack/cocaine addiction. In a precedent study, supported by a grant MILDT / INSERM 2000, on 155 men dependent to crack/cocaine and characterised with three clinical dimensions -sensation seeking, impulsivity and childhood ADHD- we found an association between each dimension and polymorphisms of DRD2 and DRD4 genes.

Enrollment: 600 estimated patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of cocaine abuse/dependence according to DSM-IV-TR criteria
• Come from French West Indies (3 grandparents are African-Caribbean)
• Sign a written informed consent

Exclusion criteria

• Minor
• Men with no cocaine abuse/dependence according to DSM-IV-TR criteria

For the control:

Inclusion Criteria:

• Platelets donor
• No substance abuse/dependence according to DSM-IV-TR criteria
• Come from French West Indies (3 grandparents are African-Caribbean)
• Sign a written informed consent

Exclusion Criteria:

• Minor
• Men refusing a genetic study

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)