A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer

Zhujiang Hospital

Status: Enrolling

Conditions: Colorectal Cancer

Treatments: Other: observational study, no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06379412

Zhujianghmy

Details and patient eligibility

About

The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC). The main question it aims to answer is: Are peptidoglycan fragments from the gut microbiota associated with the progression of colorectal cancer? Participants will provide biological specimens (blood, feces, colon tissue obtained during surgery)

Full description

To explore whether peptidoglycan fragments can be used as screening or diagnostic indicators for colorectal cancer

Enrollment: 200 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• People who underwent total colonoscopy in gastroenteroscopy room.
• People who agree to participate in this study and are willing to sign informed consent.

Exclusion criteria

• Previous diagnosis of malignant tumors other than colorectal cancer.
• Received any of the following drug treatments within 1 month before sample collection: ① Drugs used for the treatment of colorectal diseases; ② Antibiotics; ③probiotics; ④ Laxatives.
• Patients with a family history of colorectal cancer.

Trial design

200 participants in 4 patient groups

Colorectal Cancer(CRC)

Description:

People who are diagnosed with CRC by colonoscopy and pathological biopsy

Treatment:

Other: observational study, no intervention

Colorectal adenoma(CRA)

Description:

People who are diagnosed with CRA by colonoscopy and pathological biopsy

Treatment:

Other: observational study, no intervention

Colorectal polyp(CRP)

Description:

People who are diagnosed with CRP by colonoscopy and pathological biopsy

Treatment:

Other: observational study, no intervention

Healthy

Description:

People who have no obvious abnormality in the whole colon

Treatment:

Other: observational study, no intervention