A Decentralized Study on Dietary Influences on Cognitive Functions

Agency for Science, Technology and Research (A*STAR)

Status

Completed

Conditions

Cognitive Function

Glucose Metabolism

Treatments

Other: Intervention

Other: Control

Study type

Interventional

Funder types

Other

Identifiers

NCT05801731

2022-059

Details and patient eligibility

About

The current study aims to investigate the cognitive effects of diet-induced blood glucose fluctuations on cognitive performance in healthy older adults over multiple days, taking advantage of the currently available techniques to continuously measure blood glucose levels and to assess cognitive performance in a real-life setting.

In this fully decentralized study, subjects will undergo two times a three-day measurement period, where their blood glucose will be continuously measured by a minimally invasive sensor and where the cognitive performance is measured at multiple time points throughout a day using a short test battery administered on their mobile phone. In addition to receiving standardized breakfast and lunch meals, the subjects are administered a low-GI(Glycemic Index) or normal-GI(Glycemic Index) snack in the morning and afternoon.

Full description

The study has two main scientific objectives. First, the investigators aim to investigate the acute effect of a low versus high-GI snack taken mid-morning or mid-afternoon on cognition, appetite, alertness and mood. To this end the investigators will compare the pre-snack and ~2-hour snack measurements of the two snacks. The investigators hypothesize that the low-GI(Glycemic Index) snack, due to a blunted and sustained PPGR, leads to better cognition, appetite and alertness ratings. Secondly, the investigators aim to explore how daily fluctuations in blood glucose are associated with cognition, mood, appetite and alertness in healthy older adults. To this end the investigators will conduct exploratory correlational analyses between blood glucose parameters, the behavioural outcomes, and subject characteristics.

Enrollment

28 patients

Sex

All

Ages

50 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged 50 - 65 years
Own and use a smartphone that is capable to run the study applications (Android 4.4 or later, OS 12.0 or later)
Adequate fluency in the English language to understand the inform consent process, study instructions and study assessments
Sufficient vision and hearing to complete study procedures based on medical judgment
Willing and able to participate and to give written consent to comply with study procedures

Exclusion criteria

Presence or history of a metabolic, neurological, or psychiatric disease
Use of prescription or OTC medication that may influence gastrointestinal, metabolic or neurological functioning
Any health, functional or lifestyle factor that in the judgement of the investigator may interfere with the ability to comply with study procedures and/or the generation of valid study data
Known food allergies
Use of illicit drugs
Alcohol intake >1 units/day • BMI <18.5 or >30 kg/m²
Are a member of the research team or their immediate family members. Immediate family member is defined as spouse, parent, child, or sibling, whether biological or legally adopted