A Double Blind Crossover Study on the Effect of MPH on Decision-making Ability of Adults With BPD Compared to Adults With ADHD and Healthy Adults

Shalvata Mental Health Center

Status

Unknown

Conditions

Borderline Personality Disorder

Treatments

Drug: methylphenidate

Study type

Interventional

Funder types

Other

Identifiers

NCT01426984

SHA -0011-11

Details and patient eligibility

About

The study assesses the effect of Ritalin on working memory,attention,and decision-making measures in adults with BPD and compares it to its effect on healthy adults and adults with BPD (using data form study SHA 01-10), in a double-blind crossover design. The investigators hypothesize that Ritalin will result in better performance in all measures.

Full description

Participants will be required to arrive at the cognitive laboratory in "Shalvata" for two visits: the first visit will include obtaining informed consent, screening (as detailed below), and performing a battery of computerized tasks. The second visit will include performing of the same battery of tasks, and payment.

In one of the visits, participants will receive a capsule containing Methylphenidate or placebo (MPH; Ritalin) (dosage: 10 mg in case weight<40 kg; 30 mg in case weight>90 kg; otherwise 20 mg -( The pills will be 10mg each, and the number of pills will be administered according to the dosage stated; 1-3 pills, according to weight). Prior to performing the tasks, and in the other visit they will receive a capsule containing placebo.

Enrollment

20 estimated patients

Sex

All

Ages

21 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adults in the age of 21-50 with diagnosed with Borderline Personality Disorder (BPD)

Exclusion criteria

People diagnosed with a clinical disorder other than BPD or ADD/ADHD that may impair their performance in the tasks used in the study.
People for whom there is a contra-indication for consuming Ritalin.
Pregnant women and nursing women; Women participants will be required to report whether they are pregnant, and in case they are, they will not participate.