A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery

Yonsei University

Status: Completed

Conditions: General Anesthesia

Treatments: Drug: Neostigmine; Drug: Sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT01980069

4-2013-0451

Details and patient eligibility

About

Investigators hypothesized that the surgical condition will be improved with the use of sugammadex in patients undergoing laryngeal microsurgery. Investigators will compare the effect of sugammadex and neostigmine on the surgical condition during laryngeal microsurgery.

Enrollment: 72 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients of age over 20 years
• scheduled for laryngeal microsurgery under general anesthesia

Exclusion criteria

• anticipated difficult intubation, cervical spine disease, neuromuscular disease, acute or chronic renal failure, liver cirrhosis or liver failure
• history of allergy to nondepolarizing muscle relaxant
• history of malignant hyperthermia
• pregnant woman
• body mass index over 35 kg/m2

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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72 participants in 2 patient groups

Neostigmine arm

Experimental group

Description:

Neostigmine arm

Treatment:

Drug: Neostigmine

Sugammadex arm

Active Comparator group

Description:

Sugammadex arm

Treatment:

Drug: Sugammadex