A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

Nivalis Therapeutics

Status and phase

Completed

Phase 1

Conditions

Drug Interaction Potentiation

Treatments

Drug: N91115

Drug: Rifampin

Study type

Interventional

Funder types

Industry

Identifiers

NCT02500667

N91115-1H-04 (SNO-5)

Details and patient eligibility

About

The present study is designed to assess the effects of Rifampin on the pharmacokinetics of N91115 in healthy subjects.

Full description

This study will assess the effects of multiple oral dose administration of rifampin on the steady state plasma pharmacokinetics (PK) of N91115 in healthy subjects.

Eligible subjects (n=15) will receive oral doses of N91115 twice daily (approximately every 12 hours) on Study Days 1 through the morning of Day 13. On Study Days 8 through 12, rifampin administered 600 mg once daily will be added to the N91115 regimen. Study subjects will be monitored for safety while housed in the clinical research unit (CRU) until discharge on Day 14. Pharmacokinetics will be followed from Study Day 1 through Study Day 14. A follow-up phone call will be made on Day 20 (1 day). Participation of an individual subject may last up to approximately 48 days from the time of screening until the end-of-study follow-up call.

Enrollment

15 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Subject voluntarily agrees to participate in this study; signs an IRB-approved informed consent
Subject is healthy as determined by the screening medical evaluation (including but not limited to medical history, physical examination and clinical laboratory evaluations)
Subject is Caucasian
Female subject must be of non-childbearing potential or post-menopausal
Male subject must agree to use a condom with spermicide and refrain from sperm donation from Day -1 until 30 days post last dose or have a vasectomy at least 6 months prior to screening
Subject is a non-smoker
Subject has a body weight > 45 kg and BMI between 18 and 32 kg/m2
Subject has no clinically significant vital signs finding at screening or Day -1, per the investigator's judgment
Subject has no clinically significant abnormal findings in 12-lead ECG , per the investigator's judgment, at screening

Exclusion criteria

Subject has clinically significant history or evidence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological, immunological, or psychiatric disorder(s)
Subject has abnormal 12-lead ECG at screening per protocol
Subject has any disorder that would interfere with the absorption, distribution, metabolism or excretion of drugs
Subject has any concurrent disease or condition that, in the opinion of the investigator, would make the subject unsuitable for participation in the clinical study
Subject is a current alcohol abuser and/or has a history of illicit drug abuse within 1 year prior to dosing
Subject has a positive screening test for Hepatitis B surface antigen, Hepatitis C antibody, or human immunodeficiency virus (HIV) antibody
Subject is unwilling to refrain from consumption of coffee and caffeine-containing foods and beverages from Day -1 until discharge on Day 14
Subject is unwilling to abstain from using alcohol beverages from Day -1 until discharge on Day 14
Subject has donated blood (> 500 mL) or blood products within 56 days prior to Day -1
Subject has used over-the-counter (OTC) medications (including vitamins) from Day -7, or prescription medications, or herbal remedies from Day -14 until end-of-study follow-up call. By exception, acetaminophen ≤ 1000 mg/day is permitted except within 48 hours prior to Day -1 and hormone replacement therapy (HRT) is allowed throughout the study
Subject has used an investigational drug within 30 days prior to Day 1 dosing
Subject has a history of bleeding disorders