A Feasibility Study of a Low Tidal Volume Ventilation Strategy in One Lung Ventilation

University of Dublin, Trinity College

Status: Completed

Conditions: Low Tidal Volume Ventilation

Treatments: Procedure: tidal volume ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT03467607

2016-11 List 43 (1)

Details and patient eligibility

About

A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.

Full description

This study investigated the feasibility of low tidal volume ventilation for one lung ventilation.

45 patients were recruited - 15 patients in each of three groups, 3ml/kg, 4ml/kg or usual care.

Outcomes studied were length of stay, 30 day mortality, unplanned ICU admission, evidence of respiratory failure or requirement for non-invasive ventilation, chest x-ray infiltrates and requirement for antibiotics.

Enrollment: 45 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA I-III lung resection surgery requiring one lung ventilation

Exclusion criteria

• ASA IV or above under 18 or over 80 years of age pregnancy previous lung lobectomy or pneumonectomy requirement for massive transfusion during the case BMI > 35

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

3ml/kg

Active Comparator group

Description:

15 patients ventilated with 3ml/kg ideal body weight while on one lung ventilation

Treatment:

Procedure: tidal volume ventilation

4ml/kg

Active Comparator group

Description:

15 patients ventilated with 4ml/kg ideal body weight while on one lung ventilation

Treatment:

Procedure: tidal volume ventilation

control

Active Comparator group

Description:

15 patients ventilated using the anaesthetists usual ventilation strategy

Treatment:

Procedure: tidal volume ventilation