A First-in-human Study to Learn How Safe BAY 3713372 is and How it Works in Participants With MTAP-deleted Solid Tumors

Bayer

Status and phase: Enrolling; Phase 2; Phase 1

Conditions: MTAP-deleted Solid Tumors

Treatments: Drug: BAY 3713372

Study type: Interventional

Funder types: Industry

Identifiers

NCT06914128

2025-520623-24-00 (Registry Identifier)

22931

Details and patient eligibility

About

The study treatment, BAY 3713372, is under development to treat MTAP (methylthioadenosine phosphorylase)-deleted solid tumors. It is thought to work by blocking the protein arginine N-methyltransferase 5 (PRMT5). This may kill the MTAP-deleted cancer cells while sparing the normal cells.

The main objective of this first-in-human study is to learn how safe BAY 3713372 is, how the body processes it, and how well it works in people with MTAP-deleted solid tumors.

For this, the researchers will study and analyze:

• the number of participants who have adverse events (AEs) after receiving different doses of BAY 3713372 and the AE's severity.
• the number of participants who experience dose-limiting toxicities (DLTs) after receiving different doses of BAY 3713372, the DLT's severity and how often they happened. A DLT is a pre-defined medical problem caused by a specific dose of a drug that is too severe to continue using that dose.
• the total amount of BAY 3713372 in participants' blood (also called AUC) over time after single and multiple doses.
• the highest level of BAY 3713372 in participants' blood (also called Cmax) after single and multiple doses.

Other than the main objective, researchers will also check for the number of participants who show a response to treatment and how long they live without the cancer getting worse.

The study participants will take part in one of the seven distinct groups or "intervention cohorts" of the study. The study will start with a dose escalation phase where distinct groups of participants will receive different doses of BAY 3713372 alone to find the dose that is deemed safe and works best for the participants. When this dose has been found, a larger number of participants will receive BAY 3713372 alone or with other treatments in a dose expansion phase.

Participants may take the study treatment as long as they benefit from the treatment without any severe medical problems.

Participants will visit the study site:

• at least twice before the treatment starts
• multiple times when they start taking the treatment
• once after 30 days of receiving the last dose and every 9 weeks after that until the cancer worsens, or the participant stops for any other reason

During the study, the doctors and their study team will:

• check participants' health by performing tests such as blood and urine tests, and checking heart health using an electrocardiogram
• check if the participants' cancer has grown and/or spread using computed tomography (CT) or magnetic resonance imaging (MRI) and, if needed, bone scan
• take tumor samples

The study doctors and their team will contact the participants every 3 months until 2 years after the last participant's last dose or the end of the study to learn about the participant's health.

Enrollment: 370 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participant must be ≥ 18 years old of age, or the legal age of consent in the jurisdiction of the country in which the study takes place, at the time of signing the informed consent.
• At least one measurable lesion that would qualify as target lesion by Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST 1.1).
• Homozygous MTAP-deletion identified through molecular testing from a locally certified laboratory.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Exclusion criteria

• Previous additional cancer else than the one evaluated in this study within the past 2 years except for basal or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, superficial bladder tumors, localized prostate cancer or other tumors that in the opinion of the investigator, are considered cured or not immediately life-threatening, and will not interfere with the scientific goals of this study.

• A marked prolongation of QT/QTc interval at screening (e.g., repeated demonstration of a QTc interval >450 ms). Participants with permanent pacemakers (i.e., a paced rhythm) may be eligible based on the investigator's clinical assessment and discretion.

• Cardiac history comprising:

  • History of congestive heart failure Class >II according to the New York Heart Association Functional Classification.
  • Myocardial infarction less than 6 months before the start of study intervention.
  • Serious cardiac arrhythmias requiring treatment or any clinically important abnormalities in rhythm, conduction or morphology on resting ECG with the exception of atrial fibrillation which is well-controlled and requires only digoxin or beta blockers.

• Unstable angina within 4 weeks before start of study intervention.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

---

370 participants in 8 patient groups

Dose Escalation (Intervention Cohort 1)

Experimental group

Description:

For the escalation part, different dose levels of BAY 3713372 administered as monotherapy are planned.

Treatment:

Drug: BAY 3713372

Backfill cohorts in Intervention Cohort 1 (Dose Escalation)

Experimental group

Description:

Backfill cohorts may be initiated concurrently with dose escalation cohorts to generate additional safety, pharmacokinetic, and pharmacodynamic data to facilitate the selection of the optimal doses for use in further development.

Treatment:

Drug: BAY 3713372

Dose Expansion (Intervention Cohort 1)

Experimental group

Description:

Dose expansion with BAY 3713372 monotherapy in selected participants with MTAP-deleted solid tumors.

Treatment:

Drug: BAY 3713372

Dose Expansion (Intervention Cohort 2)

Experimental group

Description:

Dose expansion with BAY 3713372 monotherapy in participants with MTAP-deleted non-small cell lung cancer (NSCLC).

Treatment:

Drug: BAY 3713372

Dose Expansion (Intervention Cohort 3)

Experimental group

Description:

Dose expansion with BAY 3713372 in combination with other treatments in participants with MTAP-deleted NSCLC.

Treatment:

Drug: BAY 3713372

Dose Expansion (Intervention Cohort 4)

Experimental group

Description:

Dose expansion with BAY 3713372 in combination with other treatments in participants with MTAP-deleted NSCLC.

Treatment:

Drug: BAY 3713372

Dose Expansion (Intervention Cohort 5)

Experimental group

Description:

Dose expansion with BAY 3713372 monotherapy in participants with MTAP-deleted pancreatic ductal adenocarcinoma (PDAC).

Treatment:

Drug: BAY 3713372

Dose Expansion (Intervention Cohort 6)

Experimental group

Description:

Dose expansion with BAY 3713372 in combination with other treatments in participants with MTAP-deleted PDAC.

Treatment:

Drug: BAY 3713372