A Global Approach to Tackle Cognitive Decline

The Chinese University of Hong Kong

Status: Active, not recruiting

Conditions: Dementia

Study type: Observational

Funder types: Other

Identifiers

NCT05479318

2022.119

Details and patient eligibility

About

The number of people suffering from dementia in Asia (22.9 million) is more than twice the numbers in Europe (10.5 million) or the Americas (9.4 million), as recorded in the global impact of dementia in the World Alzheimer Report 2015.1 This dementia tsunami will continue to rise and the estimated number is 67 million in 2050 in Asia alone, which will be 2 to 3 times higher than the estimates for Europe (19 million) or the Americas (30 million). Devising and implementing preventive strategies against dementia is of paramount importance. The proposed project will be able to establish the associations between VRFs and cognition across cohorts with cultural, ethnical, and demographical variations. This study will generate data for evidence-based knowledge for globally implementable and effective preventive strategies for cognitive impairment and dementia.

Full description

Participants will be retrospectively selected from a Hong Kong Chinese cohort, a Singaporean cohort, a British cohort, two European cohorts, and an Australian cohort.

Subjects from the above listed cohorts who fit the study criteria will be selected for this study.

Demographical information, clinical, vascular risk factors, MRI images and cognitive data will be retrieved from the cohorts.

Enrollment: 1,502 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Elderly community-dwelling individuals aged over 60 years old;
2. those with at least 2 time points of detailed cognitive measurements, with 2-3 years of assessment interval;
3. with at least 1 timepoint of MRI (T1, FLAIR, and DTI).

Exclusion criteria

1. subjects with stroke, dementia, and other neurological diseases at baseline;
2. those without longitudinal cognitive data;
3. those without MRI data available.